Alogliptin is a selective, orally bioavailable dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the amount of insulin produced by your body. Besides controlling Type-2 diabetes, Alogliptin Benzoate may also eliminate the cardiovascular disease by preventing the toll-like receptor 4 (TLR-4). These receptors can increase the chances of inflammation, further increasing the atherosclerotic disease process, the main cause of cardiovascular disease.
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What is Alogliptim Benzoate?
Product Description
Molar Weight: 339.4
SMILES: CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N.C1=CC=C(C=C1)C(=O)O
InChIKey: ZSBOMTDTBDDKMP-OAHLLOKOSA-N
ALogP: 0.39
Solubility: DMF: 0.1 mg/ml, DMSO: 0.1 mg/ml, Ethanol: slightly soluble, PBS (pH 7.2): 10 mg/ml
Storage: -20°C
Stability: ≥ 2 years
CAS Number: 850649-62-6
Chemical Formula: C18H21N5O2•C7H6O2
Therapeutic Category: Antidiabetic
Form: Tablet
Assay: NLT 99.0%
Suitable for: Adults
IUPAC Name: 2-({6-[(3R)-3aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile monobenzoate
Approved Indications: 1
As per the clinical trials, there is one approved indication of Alogliptin Benzoate drug:
- Diabetes Mellitus, Type-2
Experimental Indications: 7
As per clinical trials 1-4, the drug can be used in the following categories:
- Acute Coronary Syndrome (Phase 3)
- Diabetes Mellitus ()
- Diabetes Mellitus, Type 2 ()
- Healthy Volunteers (Phase 1)
- Non-alcoholic Fatty Liver Disease (Phase 4)
- Pharmacokinetics (Phase 1)
- Pharmacology, Clinical (Phase 3)
Clinical Trials:
A total of 60 trials took place in 4 phases. 13 organizations participated in these trials.
Side Effects
Major side effects observed after the consumption of Alogliptin are:
- Upper respiratory tract infection
- Common cold
- Headache
Conclusion
Alogliptin Benzoate is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor used to treat type-2 diabetes. The drug has a molar mass of 339.4 g/mol and does not inhibit cytochrome P450 enzymes. The drug is actively used in making medications for type-2 diabetes patients. Besides that, it also has several other experimental indications, including Acute Coronary Syndrome, Non-alcoholic Fatty Liver Disease, etc. Some common side effects are headaches and the common cold.
Product CAS No
850649-62-6
Therapeutic Action
Alogliptin increasing the amount of insulin in our body, which is a type of hormone that control sugar leval in our blood in people with type 2 diabetes, also help prevent kidney damage.
