SAK-3

SAK 3 is a potent Ca_V3.1 and Ca_V3.3 activator. Enhances Ca_V3.1 and Ca_V3.3, but not Ca_V3.2 activity at concentrations of 0.01 – 10 M in neuro2A cells in vitro. Elevates ACh levels in the hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice.