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Tenofovir Alafenamide Fumarate

Tenofovir Alafenamide Fumarate

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What is Tenofovir Alafenamide Fumarate?

Tenofovir alafenamide fumarate, also known as Vemilidy, is an antiviral drug commonly used to treat hepatitis B. This antiviral fixed-dose combination drug has a molar mass of 476.474 g·mol−1 and is sold by Genvoya, Odefsey, and Descovy.

Product Description

Molar Mass: 476.474
SMILES: CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)Oc3ccccc3
ALogP: 2.97
CAS Number: 379270-37-8
Chemical Formula: C21H24D5N6O5P .C4H4O4
Therapeutic Category: Antiviral
Form: Tablet
Storage: -20C in Freezer
Suitable for: Adults
Drug Class: Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor.
Isopropyl (2S)-2-[[[(1R)-2-(6-aminopterin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphoryl]amino]propanoate.

Approved Indications (1):

As per the clinical trials, there is one approved indication of Tenofovir Alafenamide Fumarate drug:

  • Immune System Diseases

Experimental Indications (54):

As per clinical trials 1-4, the drug can be used in the following categories:

  • Anesthesia and Analgesia (Phase 1)
  • Bone Diseases, Metabolic (Phase 4)
  • Hepatitis B virus (Phase 4)
  • Hepatitis C, Chronic (Phase 4)
  • Hepatitis D, Chronic (Phase 2)
  • Herpes Simplex (Phase 1)
  • HIV Seropositivity (Phase 3)
  • Infectious Disease Transmission, Vertical (Phase 4)
  • Insulin Resistance (Phase 1)
  • Kidney Transplantation (Phase 4)
  • Leukemia, Lymphoid (Phase 2)
  • Liver Transplantation (Phase 4)
  • Lymphoma, Large B-Cell, Diffuse (Phase 2)
  • Multiple Sclerosis, Relapsing-Remitting (Phase 2)
  • Neoplasms (Phase 3)
  • Opioid-Related Disorders (Phase 4)
  • Sexually Transmitted Diseases (Phase 4)
  • Tuberculosis, Pulmonary (Phase 2)
  • Virus Diseases (Phase 4)

Clinical Trials (154):

A total of 154 trials were carried out in four phases. 182 organizations took part in the trial.

Side Effects

Common side effects seen with the consumption of this medication are:

  • Headache
  • Nausea
  • Tiredness
  • Cough

Consult with your doctor if you see mental illness, kidney problems, liver and blood problems, and lactic acidosis. 


Tenofovir alafenamide fumarate is an antiviral drug that is used in the treatment of the hepatitis B virus. This fixed-dose combination drug is also sometimes used in treating HIV. It has a molar mass of 476.474 g·mol−1 and is commonly sold by Vemilidy. You can take this drug orally with a 25 mg per day dosage. Some common side effects can include headache, nausea, and tiredness.

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