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Trelagliptin succinate

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What is Trelagliptin Succinate?

Trelagliptin Succinate is a fluorinated derivative of Alogliptin, which treats Type-2 Diabetes. It is a highly selective Dipeptidyl Peptidase -4 inhibitor that activates the T-cells. Trelagliptin Succinate has a chemical formula of C22H26FN5O6 and is also represented as SYR 111472 succinate. The parent compounds used to prepare this fluorinated salt are CID 15983988 (Trelagliptin) and CID 1110 (Succinic acid).

Product Specification

Molar Mass: 357.39
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(Cc3cc(F)ccc3C#N)C1=O
ALogP: 0.53
CAS Number: 1029877-94-8
Chemical Formula: C22H26FN5O6
Therapeutic Category: Antidiabetic
Form: Tablet
Assay: NLT 99.0%
Storage: Trelagliptin Succinate should be stored in a cool and dry place, away from humidity.
Storage Temp: +5°C
IUPAC Name: 2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)-4-fluorobenzonitrile. Its chemical structure can be represented as:

Experimental Indications:

As per clinical trials 1-4, the drug can be used in the following categories:
Endocrine system disease
Nutritional and metabolic disease
Pathological conditions
Urogenital disease
Diabetes Mellitus Type-2

Clinical Trials:

A total of 15 clinical trials were held for trelagliptin succinate in four phases. Four major companies took part in the trials. The categories for which the trials were held are as follows:

Side Effects:

Some of the common side effects that may be seen with the overdose of Trelagliptin are:

  • Hypoglycemia
  • Nasopharyngitis
  • Elevated Lipase


To conclude, we can say that Trelagliptin Succinate is an excellent DDP-4 inhibitor that treats type-2 diabetes. It improves adults’ glycemic control and makes the body sensitive to the insulin produced. Trelagliptin Succinate has a chemical formula of C22H26FN5O6 with a molar mass of 357.389 g·mol−1. It is usually given in tablet form with a 100mg dosage per week. However, patients with acute renal failure and kidney dysfunction may have to consult with their doctors before taking this medicine.

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