Tenofovir Alafenamide Fumarate: Uses, Side Effects and Precautions

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Tenofovir Alafenamide Fumarate: Uses, Side Effects and Precautions

What is Tenofovir Alafenamide Fumarate?

Tenofovir Alafenamide Fumarate is used to treat chronic Heptitis B infection and viral liver infection. The mechanism of this drug works by slowing the growth of the virus. Chronic arthritis infection may lead to serious liver damage, such as liver cirrhosis or liver cancer. There is no such clinical report where you can get the assurance that Tenofovir Alafenamide Fumarate API can completely cure hepatitis B or that it can prevent you from passing the virus to others. This article will give you a brief idea about the drug, its uses, side effects, and precautions you have to take beforehand to avoid any kind of negative repercussions. 

API Information 

An active pharmaceutical ingredient (API) called tenofovir alafenamide fumarate (TAF) is used to make antiretroviral medications that treat human immunodeficiency virus (HIV) infection. Following are some fundamental details regarding Tenofovir alafenamide fumarate API:

(R)-9-((R)-2-(6-Amino-2-(isopropylamino)-9H-purin-9-yl) is the chemical name.-1-methyl-ethoxy)-3,6-dioxo-2,5-dioxo-hexahydro-2H-pyrimidin-1-yl)methyl)-3-methyl-but-2-en-1-yl)-2-(Phenylmethoxy)-3,4-dihydro-2H-benzo[d][1,3]dioxol-5-yl]Melamine fumarate

Formula for a molecule: C22H29N6O12P

Weight in molecules: 720.47 g/mol

Tenofovir is an acyclic nucleotide analog of adenosibne. It is used with a combination of other agents in the therapy of the human immunodeficiency virus. As of now, this drug does not appear to be the significant cause of drug-induced liver injury. It belongs to the class of HIV drugs called nucleoside reverse transcriptase. Tenofovir is a member of the class of phosphonic acids, which is methyl phosphonic acid in which the methyl hydrogens are replaced by an oxy group named [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl].

Mechanism of Action 

A nucleotide reverse transcriptase inhibitor (NRTI), such as tenofovir alafenamide fumarate, prevents the action of the reverse transcriptase enzyme, which is required for HIV replication. Inside the HIV-infected cells, it is transformed into tenofovir diphosphate, which is how it functions. As the viral DNA chain grows, tenofovir diphosphate competes with normal nucleotides for inclusion, prematurely terminating the chain and preventing viral reproduction.

Clinical Trials of Drug

As an active pharmaceutical ingredient (API) for the treatment of human immunodeficiency virus (HIV) infection, TAF has been thoroughly investigated in clinical studies. Tenofovir disoproxil fumarate (TDF), the drug that TAF is based on, has been demonstrated to have similar efficacy. However, TAF may have better renal and bone safety profiles because of its distinct pharmacokinetic features, which enable lower dosage and decreased systemic exposure.

TAF has undergone safety, effectiveness, and tolerance assessments in clinical studies in a variety of groups, including treatment-experienced and treatment-naive adults with HIV-1 infection, as well as paediatric patients. TAF has been evaluated in these trials both alone and in combination with other antiretroviral medications, including emtricitabine, elvitegravir, cobicistat, and darunavir.

Clinical Use of Tenofovir Alafenamide Fumarate

  • Before starting treatment with this medication, it would be best if you consult the doctor beforehand for the HIV infection. In case you have an HIV infection along with a Hepatitis B infection, Tenofovir Alafenamide must be the only drug to treat the HIV infection. 
  • There should be a combination for the treatment of HIV infection. 
  • Go through the patient information leaflet if that is available from the pharmacist before you start taking  Tenofovir Alafenamide. In case you have any queries, then feel free to reach out to your doctor or the nearby pharmacist. To get in-depth knowledge about the pharmaceutical raw materials that are used in this drug, you can always reach out to us at Bulat Pharmaceuticals. 
  • Oral pills are available, and you have to take this medication along with food directed by the doctor daily. 
  • In case you are on your dialysis days, then take the daily dose of the medication followed by dialysis.
  • For the effectiveness of the medication, take it at evenly spaced times. Make sure you are taking your medicine at the same time daily. 
  • In case you experience any side effects, such as vomiting or nausea, then after an hour, take another dose of Tenofovir. 
  • If the vomiting occurs more than one hour after taking the dose, then you do not have to take another dose. Take the next dose regularly. 
  • Do not take more or less of the drug than prescribed, or stop taking it until your doctor has directed you to do so. By doing this, you may make the infection worse or harder to treat, and it can have some serious side effects on your body. 
  • The dosage of Tenofovir Alafenamide Fumarate should be used based on the medical condition and response to the treatment or any other medications you may be taking. Make sure to inform your doctor and the pharmacist about all the products. 

Side Effects of Tenofovir Alafenamide Fumarate

This drug can have some unwanted side effects on your body. Even though not all of these side effects that are mentioned below may occur, if you experience any of them, then consider taking the help of the doctor or visiting the nearest hospital right away. These symptoms include:

  • Agitation
  • Bloody urine
  • Coma
  • Confusion
  • Dark urine
  • Decreased appetite
  • Decreased frequency or amount of urine
  • Diarrhea
  • Dizziness
  • Fast, shallow breathing
  • A general feeling of discomfort
  • Headache
  • Hostility
  • Increased blood pressure
  • Increased thirst
  • Irritability
  • Lethargy
  • Light-colored stools
  • Loss of appetite
  • Lower back or side pain
  • Muscle pain, cramping, or twitching
  • Nausea and vomiting
  • Right upper abdominal or stomach ache and fullness
  • Seizures
  • Sleepiness
  • Stomach discomfort
  • Stupor
  • Swelling of the face, fingers, or lower legs
  • Trouble breathing
  • Unusual tiredness or weakness
  • Weight gain
  • Yellow eyes and skin

There can be side effects you may observe, which do not need any medical attention. All these side effects may go away during the treatment as the body adjusts to the medicine. Also, healthcare professionals may be able to tell you about the ways to prevent or how you can reduce the side effects. There can be common side effects such as: 

  • Acid or sour stomach,
  • Belching
  • Cough
  • Difficulty in moving
  • Heartburn
  • Indigestion
  • Joint pain
  • Muscle stiffness

Other side effects that are not listed above may also occur in some patients. In case you notice any other side effects, then reach out to nearby healthcare professionals.

Market Scenario of Tenofovir Alfenamide Fumarate

Tenofovir Alafenamide Fumarate (TAF) is an antiretroviral drug used in the treatment of HIV infection. It is a newer and improved version of the previously used tenofovir disoproxil fumarate (TDF). TAF has gained significant popularity in the market due to its enhanced efficacy and improved safety profile.

TAF is known for its high potency, allowing for lower dosing compared to TDF, which results in reduced potential for side effects. This makes it a preferred choice for HIV treatment, as it offers similar efficacy with a lower risk of kidney and bone-related adverse effects.

In terms of market acceptance, TAF has experienced rapid growth since its introduction. It has become a key component in combination therapy regimens for HIV treatment, offering improved viral suppression and long-term management. Its efficacy, combined with the reduced risk of side effects, has made it a preferred option among healthcare providers and patients.

Conclusion

This is brief information about Tenofovir Alafenamide Fumarate. If you have any queries regarding the Active Pharma Ingredients, their usage, side effects, or chemical compositions, then you can always reach out to the team members of Bulat Pharmaceuticals. We are here to solve all your queries. 

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